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Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation
(SAGE PUBLICATIONS LTD, 2010)
Simulated public speaking (SPS) test is sensitive to drugs that interfere with serotonin-mediated neurotransmission and is supposed to recruit neural systems involved in panic disorder. The study was aimed at evaluating ...
Neurobiology of panic disorder: From animal models to brain neuroimaging
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Evidence from animal models of anxiety has led to the hypothesis that serotonin enhances inhibitory avoidance (related to anxiety) in the forebrain, but inhibits one-way escape (panic) in the midbrain periaqueductal gray ...
Physiological modifications and increase in state anxiety in volunteers submitted to the Stroop Color-Word Interference Test: A preliminary study
(Elsevier B.V., 2000-07-01)
For the experimental evaluation of new drugs with a potential anxiolytic effect, there are anima] models that can accurately predict clinical activity. However, because of ethical factors, there are few experimental models ...
Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis
(Pergamon-Elsevier Science Ltd, 2016)
Increased acute anxiety is a commonly reported behavioral consequence of sleep deprivation in humans. However, rodent studies conducted so far produced inconsistent results, failing to reproduce the same sleep deprivation ...
The hypothalamic-pituitary-adrenal axis in anxiety and panic
(Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, 2010)
This review article focuses on the differential activation of the hypothalamic-pituitary-adrenal (HPA) axis in generalized anxiety and panic. The results of experimental studies that assayed adrenocorticotropic hormone, ...
Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
(ASSOC BRASILEIRA PSIQUIATRIASÃO PAULO, 2012-06)
Objectives: To review and describe studies of the non-psychotomimetic constituent of Cannabis sativa, cannabidiol (CBD), as an anxiolytic drug and discuss its possible mechanisms of action. Method: The articles selected ...
Caracterização de um modelo experimental de ansiedade humana baseado na exibição de filmes
(Pós-Graduação em Ciências da Saúde, 2017)
Oxytocin interference in the effects induced by inhalation of 7.5% CO2 in healthy volunteers
(WILEY-BLACKWELLHOBOKEN, 2012)
Objective The objective of this study was to assess the acute effect of intranasally administered oxytocin (OT) on subjective states, cardiovascular, and endocrine parameters in healthy volunteers who inhaled 7.5% CO2. ...
THE EFFECT OF MASSIVE EXTINCTION TRIALS ON THE RECOVERY OF HUMAN FEAR CONDITIONING
(SOC MEXICANA PSICOLOGIA, 2017)
Given the mixed results in literature and the lack of human studies, a fear conditioning paradigm was used to evaluate whether the use of massive or moderate extinction trials have a differential effect on the recovery of ...
Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naive Social Phobia Patients
(NATURE PUBLISHING GROUP, 2011)
Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. Cannabidiol (CBD), one major non-psychotomimetic compound of the cannabis sativa plant, has shown ...